- Excessive sweating (hyperhidrosis), underarm wetness and moist hands can be extremely unpleasant for those they affect. The treatment of most affected areas (primarily armpits and hands) can be successfully carried out on men and women with botulinum toxin. A one-time application lasts for a long time (up to one year). It is performed in the armpit with a local anaesthetic and on the hands with nerve block anaesthesia which makes it a painless procedure.